Jacinto Lab about
António Jacinto
Scientific Director and PI
Cellular Reprogramming in Regeneration and Cancer
Our group’s main interest is to understand regenerative processes to address health challenges with high impact on quality of life.
We focus on the roles of cellular metabolism and the tissue microenvironment in regeneration and cancer. We apply systems-biology approaches and experimental methods, including advanced genetics, high-resolution microscopy, and multi-omics analytics, to study retina and fin regeneration in zebrafish, and cancer biology using human organoids. We expect that work across animal models and human in vitro systems will deepen understanding of tissue physiology and disease. Ultimately, we aim to enable better diagnostics and novel therapeutic strategies by enhancing human regenerative capacity.
Jacinto Lab team
Meet Our Team
Jacinto Lab Selected Publications
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Porfírio-Rodrigues P; Pereira T; Jacinto A; Lara Carvalho. Dachsous is a key player in epithelial wound closure through modulating cell shape changes and tissue mechanics. Journal of cell science (2025) (doi:10.1242/jcs.263674)
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Ana S Brandão; Jorge Borbinha; Telmo Pereira; Patrícia H Brito; Raquel Lourenço; Anabela Bensimon-Brito; Antonio Jacinto. A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLife 11 (2022) (doi:10.7554/eLife.7698787)
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Diana P Saraiva; Bruna F Correia; Rute Salvador; Nídia de Sousa; Antonio Jacinto; Sofia Braga; MG Cabral. Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses. Oncotarget 12 24 (2021) (doi:10.18632/oncotarget.28135)
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Diogo Paramos-de-Carvalho; Isaura Martins; Ana Margarida Cristóvão; Ana Filipa Dias; Dalila Neves-Silva; Telmo Pereira; Diana Chapela; et al. Targeting senescent cells improves functional recovery after spinal cord injury. Cell Reports 36 1 (2021) (doi:10.1016/j.celrep.2021.109334)
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Lara Carvalho; Pedro Patricio; Susana Ponte; Carl-Philipp Heisenberg; Luis Almeida; André S. Nunes; Nuno A.M. Araújo; Antonio Jacinto. Occluding junctions as novel regulators of tissue mechanics during wound repair. The Journal of Cell Biology (2018) (doi:10.1083/jcb.201804048)