Project description
Neurodegenerative diseases (NDDs) are a growing health crisis with complex origins and limited treatment options. Early neuroinflammation and dysfunction of the neurovascular unit (NVU), particularly the blood-brain barrier (BBB), are key contributors to disease progression. Plant-based diets rich in polyphenols show promise due to their anti-inflammatory properties, but most dietary polyphenols have low bioavailability. In contrast, polyphenol metabolites (PMs) are more bioavailable and BBB-permeable, yet their role in brain health remains underexplored.
The NEXUS project aims to investigate the impact of selected PMs on systemic inflammation and immune cell infiltration into the brain. Using human iPSC-derived models of the BBB and in vivo validation, NEXUS will explore whether these PMs can help prevent NDD progression by modulating immune interactions. The project brings an innovative, translational approach to nutritional neuroscience and may help shape new dietary strategies for healthy aging, in line with the UN’s 2030 Sustainable Development Goals.