Project description
Our goal is to understand how immune tolerance is maintained in the skin and oral mucosa, and how disruptions in this system can lead to inflammation and cancer. Building on our work on Keratin 76, we are investigating how keratin expression in thymic epithelial cells influences T cell education. We aim to explain how breakdowns in immune tolerance contribute to chronic inflammation, altered wound healing, and increased cancer risk, with the broader goal of informing precision immunotherapies.