Project description
Oral cancers are highly heterogeneous, and our previous work showed that mutational subclones, immune composition, and stromal context all shape tumour behaviour and metastatic potential.
We are combining whole-exome sequencing and spatial omics to map tumour subclones and their surrounding immune and stromal populations in both primary and metastatic disease. By linking genetic evolution with tissue architecture, this work aims to identify biomarkers of invasion, improve understanding of tumour ecology, and support the development of personalised diagnostic and therapeutic strategies.